Hello and welcome to Thermo Fisher Scientific.
This interactive video has been created
to give you an in-depth overview
of the Thermo Scientific Orbitrap Exploris MX mass detector.
Designed to answer the growing demand
for a routine mass monitoring system,
the Orbitrap MX is fully integrated into
the Thermo Scientific multi-attribute-method 2.0 workflow,
making it ideal for seamlessly transferring methods
established during development for use in manufacturing
and Quality Control, QC or by contract partners.
Select an item from the menu to learn more about
how the Orbitrap Exploris MX mass detector
can optimize productivity in your lab.
The Thermo Scientific Orbitrap Exploris MX mass detector
is the next-generation solution
for addressing the core challenges
in obtaining high-quality mass information
for accelerating late-stage biotherapeutic development,
commercialization, manufacturing, and Quality Control, QC.
The detector is easy to operate
with simplified system templates that's fully controlled via
Thermo Scientific Chromeleon Chromatography Data System CDS,
with built-in methods, control, data processing
and management that simplify tasks and reduce errors
for more 'right first time' analyses.
Using the Thermo Scientific EASY-IC ion source,
the Orbitrap Exploris MX mass detector
maintains QC level mass accuracy
for at least a month at a time,
while The Thermo Scientific MAM 2.0 workflow integration
provides dedicated service & implementation support.
And the simple method transfer
between the Thermo Scientific Orbitrap Exploris 240
mass spectrometer and Orbitrap Exploris MX mass detector
ensures reliable performance from system to system,
and consistent results for complete confidence
in critical decision-making.
The Thermo Scientific Orbitrap Exploris MX mass detector
incorporates specific technologies
to deliver the performance needed
for late-stage BioPharma development,
manufacturing and QC.
The Orbitrap Exploris MX mass detector
offers full MS acquisition with a mass to charge range
of 40-3000 for peptide mapping and up to 8000 available
for intact protein analysis and oligonucleotide monitoring
with the BioPharma option.
A scan rate of up to 22 Hertz ensures fast acquisition
and the system has a mass resolution of up to 180,000
at a mass to charge of 200.
With one-point mass calibration,
the Orbitrap Exploris MX mass detector
provides exceptional mass accuracy,
utilizing the internal Thermo Scientific EASY-ICTM
ion source to extend the validity
of full mass range calibration data
without changing the source setup.
It's also fully compliance-ready
with Thermo Scientific Chromeleon Chromatography
Data System control with easy-to-use
pre-defined method templates and full MAM 2.0 integration
for seamless method transfer between development and QC.
Compared to other equipment,
the Thermo Scientific Orbitrap Exploris MX mass detector
offers several distinct advantages.
With it's full MS1 acquisition,
the Orbitrap Exploris MX mass detector
offers reduced system complexity
and costs with a small system footprint.
It's high resolution of 180,000 at a mass to charge of 200,
ensures that the Orbitrap Exploris MX mass detector
doesn't miss modifications
and it doesn't rely on chromatographic separation
to avoid attribute overlapping.
The Orbitrap Exploris MX mass detector
doesn't require any major software or software tuning shift
into MAM 2.0 to transfer assays established
during development through to manufacturing.
It uses single software for all data handling and processing
to deliver superior data quality, resolution
and mass accuracy as well as full workflow integration
into MAM 2.0.
It's strong focus on multi-attribute method
and compliance readiness place the Orbitrap Exploris
MX mass detector well ahead of it's competitors
in the fields of Biotherapeutics, Mass Monitoring
and Intact Protein Analysis.
The Thermo Scientific Orbitrap Exploris MX mass detector
is an easy-to-operate precision instrument
with exceptional reliability and robust performance
ready for use in compliant spaces.
This makes it a perfect fit for BioPharma
late-stage development, manufacturing and quality control.
This detector can monitor biopharmaceutical
product quality attributes during product development,
process development and manufacturing.
The system offers superior data quality
and therefore provides high confidence in the results,
from peptide level through intact protein analysis
up to the molecular weight of monoclonal antibodies,
analyzed under denaturing and under native conditions.
It's next-generation instrument control software
offers intuitive applications for mass calibration,
system calibration, complete system checks,
easy-to-interpret diagnostics and data acquisition.
Calibration, for example, is performed with a single click
that provides consistent mass stability
for at least four weeks.
All ion transfer and mass analysis parameters
are automatically calibrated
through the instrument control software
for easier, simpler and more reliable operation.
The Orbitrap Exploris MX detector
adds unprecedented simplicity, robustness
and HRAM-enabled confidence
to Multi-Attribute Method, MAM workflows.
In addition to operational productivity,
integrated Thermo Scientific Chromeleon CDS software
provides superior MS data-processing tools
and comprehensive controls for regulated labs.
The Thermo Scientific MAM 2.0 workflow
breaks down the barriers to implementation
throughout the biotherapeutic development pipeline.
It includes hardware and software tailor-made
for development and QC to provide consistent
and high-quality reproducible results.
It ensures seamless knowledge and method transfer
from the Thermo Scientific Orbitrap Exploris
240 mass spectrometer in the development phase
to the Orbitrap Exploris MX mass detector
in the quality control phase.
This is accomplished using Thermo Scientific
BioPharma Finder software for product
and process development followed by compliance-ready
Thermo Scientific Chromeleon CDS enterprise software
for data processing and reporting
in the attribute monitoring phase of development.
Chromeleon CDS offers compliant instrument tuning
and control, secure login and audit trails
on all actions with full version control as standard.
This software features full 21 CFR Part 11
and GxP compliance-readiness for data acquisition,
processing and reporting.
Here's what one of our clients had to say
about the Orbitrap Exploris MX mass detector.
- I am Sara Carillo.
I am the Application Development Team Leader.
I am working in the characterization
and comparibility laboratory here in NIBRT.
NIBRT is a world-class facility that is focussed
on the research and training needs
of biophramaceutical companies.
In particular, our group works on developing
methods for characterization of biopharmaceutical
and the process that is behind the production
and then manufacturing of biopharmaceutical.
There are so many things that you can get
from the Thermo Scientific Exploris MX instrument.
(indistinct), accuracy, flexibility,
everything in one instrument,
and this really can support your implementation
of MAM workflow and not only,
really all the needs for biopharmaceutical characterization.
At Thermo Fisher Scientific, we understand the importance
of fast, reliable, accurate and repeatable results
across the full spectrum of research, development
and manufacturing operations in the context
of the growing global demand
for superior biotherapeutic products.
Our aim is to provide an integrated, affordable,
easy-to-use solution that enables faster delivery
of biotherapeutics through the transferability
of crucial data.
We look forward to discussing your mass spectrometry
and mass detection requirements
and sharing more about our solutions.